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DTx dreams
To:Brew Readers
Healthcare Brew // Morning Brew // Update
A new digital therapeutics pilot has some experts feeling optimistic about increased uptake.

Hi again. Healthcare works best when systems actually work together. Join us on Feb. 10 to see how one unified system helps teams move faster, see clearer, and deliver better patient care without the data chaos.

In today’s edition:

New DTx pilot holds promise

January’s AI updates

GLPs bypass PBMs

—Caroline Catherman, Cassie McGrath, Courtney Vinopal

DEVICES

Back view of a man using mobile phone that has a healthcare cross made of binary code floating above it

Brittany Holloway-Brown, Photo: Adobe Stock

Digital therapeutics (DTx) is a field that, for many players, has been rich in promises but low in profits.

DTx refers to products prescribed to treat specific diseases or disorders that are typically regulated by the FDA in the software as a medical device category. As of December 2024, the FDA has cleared 192 such devices, per a review in npj Digital Medicine.

But the field has a rocky history.

The first company to get a DTx device cleared in 2017, Pear Therapeutics, announced its bankruptcy in 2023 after struggling to find a sustainable reimbursement strategy for its apps, which it had priced at $1,000+ in 2022. Digital medicine company Akili Interactive ditched the label altogether, pivoting from a prescription to over-the-counter model after poor sales in 2023 before selling off its assets in 2024.

A new FDA pilot aims to encourage uptake through its new Technology-Enabled Meaningful Patient Outcomes (TEMPO) model, which was announced on Dec. 5. The FDA began collecting statements of interest for the pilot on Jan. 2.

Some experts are optimistic.—CC

Presented By HSBC

TECH

Healthcare Brew monthly series on AI Startups

Francis Scialabba

Welcome back to AI 411, a monthly roundup of AI announcements from across the healthcare industry.

January was a big month for announcing new agentic AI tools, from Amazon One Medical’s Health AI to OpenAI’s ChatGPT Health to Anthropic's Claude for Healthcare to Google’s MedGemma. It was also the month for two of the biggest conferences of the year: CES and the JPMorgan Healthcare Conference, which Healthcare Brew attended.

But that’s not all. Here’s your breakdown of January 2026’s AI updates.

AnswersNow. AnswersNow, an AI-based applied behavioral analysis company for autism care, announced a $40 million Series B on Jan. 21 led by private equity firm HealthQuest Capital. Money will be used to “aggressively scale” the company to reach more patients, the company said in a release.

Claim Health. On Jan. 21, Claim Health announced a $4.4 million seed funding round led by venture capital (VC) company Maverick Ventures. Claim is using AI to support revenue operations in post-acute care.

See the full list here.—CM

GLP-1S

Semaglutide injection pen or cartridge pen for diabetics and weight loss in female hand. Medical equipment for diabetes patients

Iuliia Burmistrova/Getty Images

When the Trump administration announced that it struck a deal with two major GLP-1 manufacturers last month, it was unclear how soon discounts on the weight loss drugs would extend to workers on employer-sponsored insurance.

The White House is working with Eli Lilly and Novo Nordisk to offer cheaper GLP-1s to patients enrolled in Medicare and Medicaid, as well as those who want to purchase the medications without insurance. But employers are keen to understand how soon such discounts may extend to their own medical plans, especially if they aren’t already covering the popular drugs.

“Once you have publicity around a Medicare price, I think the demand for a price that is close to that level is going to be really high,” Caroline Pearson, executive director of the Peterson Health Technology Institute, said. The White House said patients will be able to purchase GLP-1s on the direct-to-consumer market for around $350, while Medicare beneficiaries will be able to access them with a $50 co-pay. Historically, these medications have cost upwards of $1,000 a month.

As demand for the drugs remains high, Eli Lilly and Novo Nordisk recently embraced new models that seek to bypass pharmacy benefit managers and make GLP-1 coverage more financially feasible for employers.

Keep reading on HR Brew.—CV

Together With HUM Nutrition

VITAL SIGNS

A laptop tracking vital signs is placed on rolling medical equipment.

Francis Scialabba

Today’s top healthcare reads.

Stat: 37%. That’s how much drug overdose deaths declined in teens and adults ages 15 to 24 between 2023 and 2024. (the Wall Street Journal)

Quote: “I’m seriously frustrated. What is happening has zero scientific merit and is just serving an agenda, which is political and anti-vax.”—Albert Bourla, Pfizer CEO, on HHS Secretary Robert F. Kennedy Jr.’s anti-vaccine rhetoric that Bourla says is leading to lower vaccination rates and an increased risk of disease spread (Reuters)

Read: More men are signing up for clinical trials for male birth control in the US and other countries. (Stat)

Healthcare’s next chapter: Explore what’s next for the healthcare industry and what it takes to stay ahead in HSBC’s 2025 Venture Healthcare Report. Get industry insights and learn which sectors are growing. Get your copy.*

*A message from our sponsor.

Healthcare cross overlaid with stylized images of a briefcase, graduation cap, stack of money, and an apartment

Amelia Kinsinger

Access to care matters, but it’s not the biggest driver of health. Here’s how social determinants like education, social networks, and chronic stress shape patient outcomes, why factors outside the clinic can outweigh genetics, and what clinicians and policymakers can do to address the root causes of poor health.

Read now

JOBS

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✳︎ A Note From HUM Nutrition

Disclaimer: *10g of prebiotic fiber (the amount in 4tsp. of Flatter Me Fiber) was clinically shown to increase GLP-1 2x 30 minutes after a meal and remain elevated for 4 hours compared to a placebo in a randomized controlled trial. Ye et al. Nutrition Research. 2015.

         
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