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These are the biggest M&A deals we saw in 2025 and what’s expected in 2026.

Happy Wednesday, especially for the needle-averse. Novo Nordisk’s new Wegovy GLP-1 pill officially became available at the beginning of this week at around the same price as its injectable after receiving FDA approval on Dec. 22—a move that’s long been speculated as the next evolution of the drug. New year, new GLP-1s?

In today’s edition:

Biggest M&A of 2025

December’s hirings and firings

🩺 ICYMI: Our 10th Quarter Century Project story

—Cassie McGrath, Maia Anderson

M&A

Hospital cross symbol with money coming out of it.

Anna Kim

As guaranteed as a new Hallmark movie at this time of year, so comes Healthcare Brew’s rundown of the biggest deals of 2025.

We reviewed public notices of the largest mergers and acquisitions (M&A) and buyouts so far this year in collaboration with global market data research company PitchBook to create a list of the biggest US healthcare M&A as of Dec. 10.

Here’s PitchBook’s list of the 10 largest deals of 2025:

  1. Pharma and medical device company Abbott announced the acquisition of molecular diagnostics company Exact Sciences for $23 billion on Nov. 20.
  2. Private equity firms Blackstone and TPG agreed to acquire women’s health company Hologic for $18.3 billion on Oct. 21.
  3. Lab equipment company Waters Corp. announced July 14 the acquisition of medtech Becton, Dickinson and Company’s biosciences and diagnostic solutions business for $17.5 billion.

See the full list here.—CM

From The Crew

EXEC MOVES

Healthcare Brew's August on Rotation editorial feature

Francis Scialabba

We’re officially in a new year! But 2025 ended with some executive shake-ups we have to keep you posted on.

Here at Healthcare Brew, we publish a monthly noncomprehensive roundup of leadership changes everywhere from healthcare startups to market-leading mega corporations, including another FDA departure.

Welcome to December’s On Rotation.

Have a job announcement to share? Drop Caroline an email at [email protected].

Selwena Brewster. NYC Health + Hospitals/South Brooklyn Health announced Brewster as chief medical official on Dec. 2. She previously served as associate chief medical officer at NYC Health + Hospitals/Kings County.

Kevin Hammons. After serving as interim CEO of for-profit Franklin, Tennessee-based Community Health Systems since Oct. 1, Hammons officially stepped into the role on Dec. 10. Jason Johnson also officially became CFO on the same day.

See the full list here.—CM

PRIVATE EQUITY

Rear view of female caregiver assisting senior woman walking with mobility walker in corridor

Maskot/Getty Images

While all of healthcare suffered during the Covid-19 pandemic, nursing homes were hit particularly hard.

At the start of the pandemic, nearly half of all Covid deaths were people living or working in long-term care facilities, according to data from KFF. By early 2022, more than 200,000 people had died from the virus, making up roughly 23% of all Covid-related deaths in the US, KFF found.

Part of this can be attributed to the fact that nursing home residents tend to be at higher risk for contracting viruses due to their age, and living close together means it’s easier for illness to spread.

But some of the blame may lie in the fact that nursing homes are chronically short-staffed and run on extremely thin margins—often 3% or less in 2020, according to a survey from the American Health Care Association and National Center for Assisted Living (AHCA/NCAL), a trade group that represents long-term care facilities.

And the fact that private equity (PE) firms are increasingly buying up nursing homes is making those troubles worse, some experts argue.

PE firms own somewhere between 5% to 13% of nursing homes in the US as of 2025, though a lack of transparency into ownership structures makes it virtually impossible to know the exact number, according to an April 2025 report from the nonprofit Private Equity Stakeholder Project (PESP).

PE-owned facilities tend to see a drop in care quality.—MA

VITAL SIGNS

A laptop tracking vital signs is placed on rolling medical equipment.

Francis Scialabba

Today’s top healthcare reads.

Stat: 11. That’s how many vaccines the CDC now recommends for children under HHS Secretary Robert F. Kennedy Jr., down from 18. (NBC News)

Quote: “There’s a reason why we’re the only country that has PBMs and our prices are higher than brands everywhere else.”—Mark Cuban, co-founder of Cost Plus Drugs, in a Johns Hopkins-hosted conversation with Optum’s CEO on pharmacy services, PBMs, and other healthcare issues (Becker’s Hospital Review)

Read: After Congress declined to extend enhanced subsidies under the ACA, beneficiaries now have to wrap their heads around much higher insurance premiums. (the New York Times)

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